Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCRArticle Published on 2022-11-042022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] addition affected amplification analyzed approach Blood carried COVID-19 pandemic Critical Ct value detect detection diagnostic diagnostic capabilities digital PCR Dilution droplet False negative Health hospital Infectious disease inhibitors invasive Laboratory less limitation Nasopharyngeal samples parameter PCR platform pool positive sample reagent reagents reduce reducing resources resulting risk Saliva SARS-CoV-2 sensitivity the SARS-CoV-2 virus load was performed [DOI] 10.1371/journal.pone.0271860 PMC 바로가기
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody CombinationArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] antibodies antibody applicability approach binding capture reagent clinical analysis Combination complementarity-determining region conditions coronavirus disease Critical demonstrated domain extension Final hybrid implementation Infection Ligand limit lining mAb macromolecules Magnetic beads matrix effect monoclonal antibody multidimensional nasal offer patient population peptide performed platform quantification reagent reagents reproducibility required sensitivity serum significantly Tandem mass spectrometry Treatment vaccination viral spike protein [DOI] 10.1021/acs.analchem.2c01320 PMC 바로가기
DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasisArticle Published on 2022-10-262022-11-15 Journal: Mutagenesis [Category] 바이오마커, 치료제, [키워드] activated Analysis Antibiotics Anticoagulant antiviral therapy applied Bearing biochemical C-reactive protein (CRP Chest chest X-ray Concentration contribute control subjects Corticosteroid COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA DNA damage female Female patients Genetic Genome genotoxic healthy control healthy controls hematological parameters Hemostasis hemostasis abnormalities hospitalized COVID-19 patient IL-6 indicated Inflammation Inflammation. Inflammatory marker Laboratory laboratory parameter Laboratory parameters leukocyte lymphocyte neutrophil parameter performed peripheral blood lymphocyte Platelet positive positive correlation positively correlated procalcitonin reagent shown significantly significantly higher smoking statistically study population subjects therapy variety viral infections was measured X ray [DOI] 10.1093/mutage/geac011 PMC 바로가기
Singleplex, multiplex and pooled sample real-time RT-PCR assays for detection of SARS-CoV-2 in an occupational medicine settingArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 2019-nCoV addition Analysis Asymptomatic CDC clinical sample condition Contact COVID COVID-19 COVID-19 disease Critical defined Detection limit diagnostic diagnostic test disease equipment FDA flexible healthcare high risk implication include Infection limit methodology multiplex overlap pandemic Pandemics Panel Patient Population positive sample progressed reagent real-time RT-PCR resource resources RT-PCR SARS-CoV-2 sensitivity spread of COVID-19 symptomatic Symptomatic patients tested Transmission was determined [DOI] 10.1038/s41598-022-22106-2 PMC 바로가기
Validation of a duplex PCR technique using the gen E and RNase P for the diagnosis of SARS-CoV-2Article Published on 2022-10-012022-11-16 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis Berlin protocol Charité clinical samples COVID-19 COVID-19 diagnosis Cribado masivo Diagnosis diagnosis of SARS-CoV-2 Diagnóstico E gene English Faculty of Medicine Genes independent Laboratory limit of detection limitations mass Mass screening no significant difference not affect PCR PCR en tiempo real polymerase chain protocol reagent real time Real-time PCR reduce reliability reported reproducibility reverse transcriptase RNA sample RNase P RT-PCR SARS-CoV-2 SARS-CoV-2. sensitivity Sensitivity and specificity similarity Spanish specificity specimen threshold validation World Health Organization [DOI] 10.1016/j.eimce.2022.05.005 PMC 바로가기
Developing a Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of Seven Respiratory Viruses including SARS-CoV-2Article Published on 2022-09-052022-11-15 Journal: Medicina [Category] SARS, 신종인플루엔자, 치료기술, 치료제, [키워드] Accuracy acute respiratory syndrome Adenovirus amplification caused coronavirus coronavirus disease COVID-19 cross-reactivity detection develop Developing diagnosis of COVID-19 evaluate facilitate Final H1N1 H3N2 heat-inactivated include Infection Influenza initial symptom isothermal isothermal amplification material median multiplex Nasopharyngeal swab objective overlap pandemic Patient patients PCR performed point-of-care polymerase chain Quantitative quantitative PCR Rapid reagent respiratory respiratory infection respiratory syncytial virus respiratory virus respiratory virus Respiratory virus. respiratory viruses RSV RT-PCR RT-qLAMP RT-qPCR RT-qPCR assay SARS-CoV-2 Sensitivity and specificity Seven specimen strain Symptom target specificity time-consuming Treatment Volume was performed were used [DOI] 10.3390/medicina58091224 PMC 바로가기
Laboratory Interventions to Eliminate Unnecessary Rapid COVID-19 Testing During a Reagent ShortageObservational Study Published on 2022-09-022022-10-04 Journal: American journal of clinical pathology [Category] SARS, 임상, [키워드] acute respiratory syndrome Analysis Computerized physician order entry coronavirus coronavirus disease COVID-19 COVID-19 test COVID-19 tests Dashboard decision Decision support decrease diagnostic evaluate facilitated informatics Intervention Laboratory Laboratory stewardship management pandemic Performing polymerase chain postintervention Rapid Rapid diagnostic test Rapid test reagent resource retrospective SARS-CoV-2 SARS-CoV-2. significantly study period Testing transcriptase [DOI] 10.1093/ajcp/aqac063 PMC 바로가기 [Article Type] Observational Study
Performance analysis among multiple fully automated anti-SARS-CoV-2 antibody measurement reagents: A potential indicator for the correlation of protection in the antibody titer여러 완전 자동화된 anti-SARS-CoV-2 항체 측정 시약 간의 성능 분석: 항체 역가의 보호 상관 관계에 대한 잠재적 지표Article Published on 2022-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed anti-SARS-CoV-2 antibody antibody Antibody detection antibody tests Antibody titer Architect automated Clinical use coronavirus correlated correlation COVID-19 detection Detection. diagnosed Elecsy Elecsys evaluate expected FIVE IgG IgM Infection late stage linearity neutralizing antibody Patient performance positive Precision Quantitative reagent reference values respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-COV-2 infection serum sample serum samples severe acute respiratory syndrome Coronavirus sVNT virus-neutralizing was used [DOI] 10.1016/j.jiac.2022.05.016 PMC 바로가기 [Article Type] Article
High-Throughput COVID-19 Testing of Naso-Oropharyngeal Swabs Using a Sensitive Extraction-Free Sample Preparation MethodArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 치료기술, [키워드] approach calibrated Cobas costly COVID-19 detection system diagnosis of SARS-CoV-2 diagnostic Direct direct method downstream extraction-free extraction-free method gold standard high-throughput. Infection International lack less log medium naso-oropharyngeal swab nasopharyngeal swab specimen nucleic acid extraction offer ORF1ab outcome PCR PCR assay per day PlexPCR pool positive sample preparation proteinase protocol purification quantification RdRP reagent reagents reduction in required Respiratory Coronavirus reverse transcription-PCR RNA Roche Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA sensitive sensitivity tested Testing time-consuming Transport Treatment Viral load Viral RNA WHO [DOI] 10.1128/spectrum.01358-22 PMC 바로가기
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article